Spongiosis is the presence of fluid between the keratinocytes in the epidermis.
Vesicular spongiosis is seen in pompholyx, Acute dermatitis, acute contact dermatitis , pemphigus vegetans, prebullous pemphigoid and eczematous drug reactions.
Non vesicular spongiosis is a feature of subacute dermatitis, Pityriasis rosea and Gianotti Crosti
Eosinophilic spongiosis - Bullous pemphigoid, Pemphigus vulgaris, Pemphigus vegetans, Insect bites, Allergic contact dermatitis, Erythema toxicum neonatorum, Incontinentia pigmenti
Accumulation of fluid within the keratinocytes leading to "reticular degeneration" is different.
Intracellular edema without spongiosis is seen in mucosal pachyonychia congenita, Oral white sponge nevus, Leukedema of oral mucosa, Oral hairy leukoplakia and Focal epithelial hyperplasia
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